An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress
Molecular Psychiatry May 25, 2021 Ju Lu, Michelle Tjia, Brian Mullen et al. 87 citations
Abstract Psychological stress affects a wide spectrum of brain functions and poses risks for many mental disorders. However, effective therapeutics to alleviate or revert its deleterious effects are lacking. A recently synthesized psychedelic analog tabernanthalog (TBG) has demonstrated anti-addictive and antidepressant potential. Whether TBG can rescue stress-induced affective, sensory, and...
DOI: 10.1038/s41380-021-01159-1 (opens in new tab)
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Somatosensory system
Premovement neuronal activity
Biological neural network