Substance Abuse and Cognitive Decline: The Critical Role of Tau Protein as a Potential Biomarker
International Journal of Molecular Sciences August 7, 2025 Liliana Rebolledo-Pérez, Jorge Hernández‐bello, Alicia Martínez-ramos et al. 5 citations
Tau protein is essential for the structural stability of neurons, particularly through its role in microtubule assembly and axonal transport. However, when abnormally hyperphosphorylated or cleaved, Tau can aggregate into insoluble forms that disrupt neuronal function, contributing to the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD). Emerging evidence suggests...