Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum
Nature Communications August 19, 2025 Maxwell B. Madden, Chloe Schaefgen, Binita Vedak et al. 4 citations
Through its widespread reciprocal connections with the cerebral cortex, the claustrum is implicated in sleep and waking cortical network states. Yet, basic knowledge of neuromodulation in this structure is lacking. The claustrum is richly innervated by serotonergic fibers, expresses serotonin receptors, and is suggested to play a role in the ability of psilocybin, which is metabolized to the...