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James Cooke

2 papers in the library · 9 citations · publishing 2024-2026

Papers

UK medical students’ self-reported knowledge and harm assessment of psychedelics and their application in clinical research: a cross-sectional study

BMJ Open March 1, 2024 Charlie Song-Smith, Edward Jacobs, James Rucker et al. 9 citations

Most UK medical students (83%) are aware of psychedelic research and only 3% are not interested in learning more, yet only 17% feel well-educated on the topic. Students' harm assessments of psychedelics closely match experts', but teaching on psychedelics is rare in their curriculum. Time in medical school does not correlate with more knowledge about psychedelics. On average, students strongly support changing the legal status of psychedelics to enable further clinical research. Greater knowledge, lower perceived harm, more years in medical school, and lower perceived effectiveness of non-pharmacological mental health treatments are associated with stronger support for legal change.

Egostasis: A First-Principles Account of the Neurocomputational Basis of Suffering

April 30, 2026 James Cooke preprint

Psychological suffering arises from prediction errors being attributed to a self-model, with chronic suffering emerging when temporally deep goal-directed policies (egostasis) override immediate allostatic adjustments, perpetuating stress signals. This self-reinforcing feedback loop, mediated by the Default Mode and Central Executive Networks, provides a transdiagnostic framework for disorders like depression, anxiety, PTSD, and addiction. Interventions such as mindfulness meditation and psychedelic-induced ego-dissolution may relieve suffering by disrupting these selfing dynamics and restoring adaptive allostasis.