Prefrontal Neurophysiological Changes Associated with Subanesthetic Esketamine Accelerating Mice Emergence from Propofol Anesthesia.
Brain Research Bulletin November 22, 2025 Yinying Sun, Bo Li, Yiting Wang et al.
Recent studies have demonstrated that subanesthetic dose of ketamine or its S-enantiomer, esketamine, can paradoxically accelerate the recovery of consciousness in rodents following general anesthesia. However, the neural mechanisms underlying this "awakening-promoting" effect remain poorly understood. Adult C57BL/6J mice were anesthetized with propofol, 0and a low dose of esketamine (2mg/kg)...