In early 2025, an unidentified white powder suspected illicit drug was submitted to National Forensic Service (NFS) for analysis and was subsequently identified as 2F-2-oxo-PCPr. 2F-2-oxo-PCPr is a structurally modified ketamine analogue characterized by the replacement of the aromatic chlorine substituent with fluorine and the substitution of the amine methyl group with a propyl group....
Fluorinated analogs of ketamine, such as 2-fluoro-deschloroketamine and its isomers, have recently emerged as dissociative anesthetics that act through multiple central nervous system pathways. As their prevalence continues to increase, metabolic studies are critical to confirm their use in suspected cases of abuse. 2-Fluoro-N-propylnordeschloroketamine (2-fluoro-2-oxo-PCPr), in which a propyl...