Structural identification and metabolic profiling of the new psychoactive substance 2-fluoro-2-oxo-PCPr using NMR and LC-QTOF-MS.
Forensic Science International November 10, 2025 Seonghoon Yeon, Jisu Park, Byungseok Cho et al.
Fluorinated analogs of ketamine, such as 2-fluoro-deschloroketamine and its isomers, have recently emerged as dissociative anesthetics that act through multiple central nervous system pathways. As their prevalence continues to increase, metabolic studies are critical to confirm their use in suspected cases of abuse. 2-Fluoro-N-propylnordeschloroketamine (2-fluoro-2-oxo-PCPr), in which a propyl...
DOI: 10.1016/j.forsciint.2025.112716 (opens in new tab)
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2-fluoro-2-oxo-pcpr
Giao-dft nmr calculations
Interconverting rotamerization
Metabolite profiling