Quantitative monitoring of ketamine's impact on synaptic density using 11C-UCB-J PET imaging in the corticosterone mouse model of anxiety/depression.
Molecular Psychiatry November 18, 2025 Cassandre Corvo, Sébastien Goutal, Indira Mendez-David et al. 1 citation
Ketamine was shown to promote synaptogenesis, which is thought to account for its antidepressant effects through the restoration of lost synaptic connections observed in depression. PET imaging using 11C-UCB-J, a radiotracer targeting the synaptic vesicle protein 2 A (SV2A), was investigated as a translational method to monitor ketamine-induced changes in synaptic density in the corticosterone...
DOI: 10.1038/s41380-025-03369-3 (opens in new tab)
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Ketamine ketamine
Single ketamine dose
Repeated doses
Neuroplasticity brain connections
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