Gestational psychedelic exposure disrupts brain development and offspring behavior in mice.
bioRxiv : the preprint server for biology September 30, 2025 Ya'El Courtney, Josephine M Anderson, Christian Lagares-Linares et al. preprint
Despite increasing non-medical use and clinical investigation of psychedelics, the consequences of prenatal exposure remain unknown. In mice, maternal lysergic acid diethylamide (LSD; 0.3 mg kg -1 ) crossed the placenta, appearing in embryonic cerebrospinal fluid (CSF) within minutes at E12.5 and E16.5. Within 30 minutes, LSD and other serotonergic psychedelics induced a 5-HT 2 C agonist-like...