Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward.
Nature Communications November 20, 2025 Alaina M Jaster, Thomas M Hadlock, Belle Buzzi et al. 9 citations
Emerging evidence suggests that classical psychedelics may offer therapeutic potential for opioid use disorder (OUD) by alleviating key hallmarks such as altered reward processing and dependence. However, the mechanisms behind these effects remain unclear. Our data demonstrate that a single administration of the psychedelic psilocybin (PSI) reduces conditioned behavior and withdrawal induced by...