Markus Wöhr

2 papers in the library · 1 citation · publishing 2018-2025

Papers

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3,4-Methylenedioxymethamphetamine (MDMA) does not induce robust psychomotor activation and 50-kHz ultrasonic vocalisations in tryptophan hydroxylase 2 (Tph2)-deficient rats lacking serotonin in the central nervous system.

British Journal of Pharmacology November 23, 2025 Tianhua Wang, Rainer K.W. Schwarting, Markus Wöhr 1 citation

3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a psychostimulant with entactogenic properties and known to induce arousal and euphoria. As an amphetamine derivate, MDMA acts on the monoamine systems in the brain and stimulates release of dopamine (DA), noradrenaline (NA) and serotonin (5-HT), yet their individual contributions in driving arousal and euphoria remain...

DOI: 10.1111/bph.70226 Full text Locomotor activity Psychostimulant Tryptophan hydroxylase 2 Ecstasy effects: ecstasy +13

Reduced Efficacy of d-Amphetamine and 3,4-Methylenedioxymethamphetamine in Inducing Hyperactivity in Mice Lacking the Postsynaptic Scaffolding Protein SHANK1.

Frontiers in Molecular Neuroscience 2018 A Özge Sungur, Tobias M Redecker, Elena Andres et al.

Genetic defects in the three SH3 and multiple ankyrin repeat domains (SHANK) genes (SHANK1, SHANK2, and SHANK3) are associated with multiple major neuropsychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BPD). Psychostimulant-induced hyperactivity is a commonly applied paradigm to assess behavioral phenotypes related to BPD and considered...

DOI: 10.3389/fnmol.2018.00419 Full text MDMA Ecstasy Serotonin Dopamine +2