Treatment resistance in bipolar depression is one of the most challenging clinical conditions to treat in psychiatry. We present a case of an elderly gentleman with chronic Multi-Therapy Resistant Bipolar Depression (MTRBD), where ketamine, a preferential NMDAR blocker on cortical GABAergic interneurons, is used adjunctively with sequential theta burst stimulation (sTBS) to achieve remission....
This paper explores pranayama, the ancient yogic practice of breath control, as a promising natural method of neuromodulation. Pranayama aims to regulate the flow of prana (life force) to enhance mental clarity, emotional balance, and physiological resilience. We synthesize evidence from clinical, neuroimaging, and psychophysiological studies, illustrating how various pranayama techniques -...
Schizophrenia patients experience a 'disconnect' at multiple levels-neuronal networks, mental processes, and interpersonal relationships. The resultant poor quality-of-life and functional disability are related to the persistent cognitive deficits and negative symptoms, which are rather resistant to conventional antipsychotic medications. Yoga has emerged as an important therapeutic...