Psilocybin desynchronizes the human brain.
Nature August 1, 2024 Joshua S. Siegel, Subha Subramanian, Demetrius Perry et al. 241 citations
A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials1-4. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus5-8. It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here...