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Olivier Pierrefiche

2 papers in the library · 8 citations · publishing 2024-2025

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[Epigenetic changes in alcohol addiction and therapeutic perspectives].

Annales pharmaceutiques francaises 2025 Olivier Pierrefiche

Alcohol consumption is a major public health issue. Patients with Alcohol Use Disorder (AUD) can benefit from five treatments that preferentially target membrane receptors, and whose efficacy is generally modest. However, a large body of experimental evidence points to an important role for epigenetics in the effects of alcohol consumption, and epidrugs that modify the epigenome offer an...

Epigenetic drugs and psychedelics as emerging therapies for alcohol use disorder: insights from preclinical studies.

Journal of neural transmission (Vienna, Austria : 1996) May 1, 2024 Fahd François Hilal, Jérôme Jeanblanc, Chloé Deschamps et al. 8 citations

Alcohol use disorder (AUD) is a public health issue that affects millions of people worldwide leading to physical, mental and socio-economic consequences. While current treatments for AUD have provided relief to individuals, their effectiveness on the long term is often limited, leaving a number of affected individuals without sustainable solutions. In this review, we aim to explore two...