João P C Leite

2 papers in the library · publishing 2024-2026

Papers

Prophylactic efficacy of cannabidiol and sodium nitroprusside in a ketamine model of schizophrenia: sex-dependent effects on positive-like and cognitive impairments

Brazilian Journal of Psychiatry June 16, 2026 Daniel B.a. Prado, Matheus T. Rossignoli, Rafael N. Ruggiero et al.

In a rat model of schizophrenia-like symptoms induced by ketamine, the combination of cannabidiol and sodium nitroprusside given during brain development prevented hyperactivity and memory problems in both sexes, while each drug alone had limited effects. The model produced different symptoms in males and females: females showed greater hyperactivity and long-term memory deficits, whereas males showed reduced pleasure-seeking and short-term memory impairments. The combined treatment was more effective in females, and distinct behavioral patterns were seen between sexes. This suggests that a combination of these two compounds may offer a sex-specific preventive strategy for schizophrenia symptoms.

DOI: 10.47626/1516-4446-2025-4301 Full text Ketamine Cannabidiol Schizophrenia Sex +1

Ayahuasca drinking using a two-bottle choice procedure in male mice.

Scientific Reports October 23, 2024 Natali D. Kisaki, Yasmim A. Serra, Isa R S Rodrigues et al.

Male mice voluntarily drank ayahuasca over water when offered every other day, regardless of concentration. Extending the interval between exposures to every five days reversed this preference, producing aversion to ayahuasca, especially at higher concentrations. Frequency of exposure and concentration together influenced total ayahuasca intake during later re-exposure. These results indicate that both how often and how much ayahuasca is available determine preference in mice, which may inform therapeutic or ritualistic use.

DOI: 10.1038/s41598-024-75077-x Full text Ayahuasca Drinking Mice Preference +8