Mindfulness-based interventions (MBIs), including Mindfulness-Based Cognitive Therapy, Acceptance and Commitment Therapy, and Dialectical Behavioural Therapy, are effective at reducing depressive symptoms across a range of psychiatric disorders. A systematic review and meta-analysis of 35 randomized controlled trials covering 12 diagnostic categories found that these interventions produced significant effect sizes compared to active control conditions. The findings suggest that MBIs can serve as a cost-effective, transdiagnostic tool for treating depressive symptoms not only in depressive disorders but across mental health conditions.
Among adolescents with early-onset psychosis, about 14% have used hallucinogens, and such use is linked to more complex clinical trajectories including higher rates of suicidality, conduct disorder, reduced educational attainment, and need for depot antipsychotic treatment. In the general adolescent population, hallucinogen use shows only weak and inconsistent associations with psychotic or manic symptoms, which largely disappear after accounting for other drug use and genetic vulnerability. The findings suggest hallucinogens are not an isolated causal trigger for psychosis but may worsen symptoms in youth with neurodevelopmental or genetic predispositions.