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Supaya Wenuganen

2 papers in the library · 2 citations · publishing 2023-2025

Papers

Possible Anti-Aging and Anti-Stress Effects of Long-Term Transcendental Meditation Practice: Differences in Gene Expression, EEG Correlates of Cognitive Function, and Hair Steroids.

Biomolecules February 20, 2025 Supaya Wenuganen, Kenneth G Walton, Frederick Travis et al. 2 citations

Long-term Transcendental Meditation practice is associated with reduced biomarkers of chronic stress and biological aging. In a comparison of older long-term meditators (average 40 years of practice) with age-matched non-meditators, 7 of 13 genes that were more highly expressed in older controls showed lower expression in the older meditators. Older meditators also scored higher on a brain integration scale and had shorter event-related potential latencies—indicating faster cognitive processing—than age-matched controls, with latencies no longer than those of young non-meditators. Hair cortisol levels were lower in meditators than in matched controls, suggesting lower cumulative stress exposure.

Transcendental Meditation practitioners show reduced expression of the Conserved Transcriptional Response to Adversity.

Brain, Behavior, & Immunity - Health October 1, 2023 Kenneth G Walton, Supaya Wenuganen, Steven W Cole

Long-term practitioners of Transcendental Meditation (TM) showed reduced expression of genes linked to inflammation and increased activity of antiviral genes, compared to matched controls. The analysis focused on a specific pattern of gene activity called the Conserved Transcriptional Response to Adversity (CTRA), which is typically elevated during chronic stress. In the TM group, inflammation-related transcription factors (NF-κB, AP-1) were less active, while interferon response factors were more active. These findings suggest a potential biological mechanism through which long-term meditation practice might improve health, though further research is needed to confirm causality.