Investigating novel pharmacological strategies for treatment-resistant depression: focus on new mechanisms and approaches
Expert Opinion on Drug Discovery January 31, 2025 Aline Silva de Miranda, Eliana C B Toscano, Venugopal Reddy Venna et al. 2 citations
The understanding of the multiple pathophysiological mechanisms involved in TRD may add further value to the effective treatment, contributing to a more personalized approach. Esketamine was approved for the treatment of TRD and novel drugs with rapid antidepressant actions such as psilocybin and buprenorphine have also been investigated as potential therapeutic strategies. Over the past...