Pallavi Nistala

2 papers in the library · 4 citations · publishing 2018-2023

Papers

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Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors.

Frontiers in Pharmacology 2023 Prithvi Hemanth, Pallavi Nistala, Vy T Nguyen et al. 4 citations

Certain 4-substituted analogs of 1-(2,5-dimethoxyphenyl)isopropylamine (2,5-DMA) are psychoactive classical hallucinogens or serotonergic psychedelic agents that function as human 5-HT2A (h5-HT2A) serotonin receptor agonists. Activation of a related receptor population, h5-HT2B receptors, has been demonstrated to result in adverse effects including cardiac valvulopathy. We previously published...

DOI: 10.3389/fphar.2023.1101290 Full text 5-ht2a 5-ht2b Ca2+ mobilization assay Qsar +3

5-HT2B Receptor-mediated Cardiac Valvulopathy

VCU Scholars Compass 2018 Pallavi Nistala

5-HT2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic, was withdrawn from the market due to causing cardiac valvulopathy. Fenfluramine, after metabolism by N-dealkylation, produces the metabolite...

DOI: 10.25772/0ynr-6690