Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands.
International Journal of Molecular Sciences January 23, 2019 Giuseppe Floresta, Maria Dichiara, Davide Gentile et al. 16 citations
Ibogaine is a psychoactive indole alkaloid with high affinity for several targets including the σ₂ receptor. Indeed, extensive data support the involvement of the σ₂ receptor in neurological disorders, including Alzheimer's disease, schizophrenia, alcohol abuse and pain. Due to its serious side effects which prevent ibogaine from potential clinical applications, novel ibogaine derivatives...