Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Nature May 1, 2019 Jonathan A. Coleman, Dongxue Yang, Zhiyu Zhao et al. 301 citations
The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the sodium- and chloride-dependent recycling of serotonin into presynaptic neurons1-3. Major depression and anxiety disorders are treated using selective serotonin reuptake inhibitors-small molecules that competitively block substrate binding and thereby prolong neurotransmitter action2,4. The dopamine and...