Structure-Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore.
ACS Pharmacology & Translational Science April 9, 2021 Thomas W. Flanagan, Gerald Billac, Alexus N. Landry et al. 50 citations
Psychedelic drugs can exert potent anti-inflammatory effects. However, anti-inflammatory effects do not appear to correlate with behavioral activity, suggesting different underlying mechanisms. We hypothesized that the distinct structural features of psychedelics underlie functionally selective mechanisms at the target 5-HT2A receptor to elicit maximal anti-inflammatory effects. In order to...
DOI: 10.1021/acsptsci.0c00063 (opens in new tab)
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5-ht2a receptor
Inflammation reduction
Inflammation suppression
Anti-inflammatory effects
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