Reactivity of the Iboga Skeleton: Oxidation Study of Ibogaine and Voacangine.
Journal of Natural Products June 23, 2023 Bruno González, Nicolás Veiga, Gonzalo Hernández et al. 7 citations
The iboga alkaloids scaffold shows great potential as a pharmacophore in drug candidates for the treatment of neuropsychiatric disorders. Thus, the study of the reactivity of this type of motif is particularly useful for the generation of new analogs suitable for medicinal chemistry goals. In this article, we analyzed the oxidation pattern of ibogaine and voacangine using dioxygen, peroxo...