A transcriptomic analysis in mice following a single dose of ibogaine identifies new potential therapeutic targets.
Translational Psychiatry January 19, 2024 Judit Biosca-Brull, Genís Ona, Lineth Alarcón-franco et al. 5 citations
Ibogaine (IBO) is an atypical psychedelic with a complex mechanism of action. To date, the mechanisms that may underlie its anti-addictive effects are still not defined. This study aims to identify changes in gene expression induced by a single oral dose of IBO in the cortex of mice by means of a transcriptomic analysis for the first time. Our results showed significant alterations in gene...