Psilocin alleviates acute itch in mice: possible involvement of 5-HT2A receptors and kynurenine pathway.
Naunyn-Schmiedeberg's archives of pharmacology April 15, 2025 Arya Afrooghe, Elham Ahmadi, Ali Lesani et al.
We aimed to investigate whether psilocin, the bioactive metabolite of the well-known psychedelic, psilocybin, may have antipruritic effects in mice by interfering with the kynurenine pathway and interacting with 5-HT2A receptors. Eight mice were randomly assigned to each of the study groups receiving either normal saline, compound 48/80, psilocin (0.3, 1, and 3 mg/kg), or psilocin (1 mg/kg) +...