Rapid and sustained antidepressant effects of vaporized N,N-dimethyltryptamine: a phase 2a clinical trial in treatment-resistant depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology May 1, 2025 Marcelo Falchi-Carvalho, Fernanda Palhano-Fontes, Isabel Wießner et al. 35 citations
Depression affects over 185 million people worldwide, with approximately one-third classified as treatment-resistant depression (TRD). Current treatments, such as oral antidepressants, often take around 3 weeks to become effective, with no immediate anti-suicidal benefits. The field urgently needs innovative therapies that provide rapid relief. Psychedelics like psilocybin and ayahuasca have...