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Alexandra Hempe

3 papers in the library · 48 citations · publishing 2023-2025

Papers

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Ayahuasca-inspired DMT/HAR formulation reduces brain differentiation between self and other faces.

Neuroimage June 1, 2025 Dila Suay, Helena Aicher, Micheal Kometer et al. 4 citations

Psychedelics are known to profoundly alter perception and self-referential processing, yet their specific effects on face recognition -particularly with regard to the recognition of face familiarity-remain underexplored. This study investigates the effects of an ayahuasca-inspired novel DMT/HAR (N,N-dimethyltryptamine/Harmine) formulation and Harmine alone on face recognition and...

Pharmacokinetics and pharmacodynamics of an innovative psychedelic N,N-dimethyltryptamine/harmine formulation in healthy participants: a randomized controlled trial.

The International Journal of Neuropsychopharmacology December 28, 2024 Michael J Mueller, Helena Aicher, Dario Dornbierer et al. 10 citations

Recent interest in the clinical use of psychedelics has highlighted plant-derived medicines like ayahuasca showing rapid-acting and sustainable therapeutic effects in various psychiatric conditions. This traditional Amazonian plant decoction contains N,N-dimethyltryptamine (DMT) and β-carboline alkaloids such as harmine. However, its use is often accompanied by distressing effects like nausea,...

Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects.

Frontiers in Psychiatry 2023 Helena Aicher, Michael J Mueller, Dario Dornbierer et al. 34 citations

There is growing scientific evidence for the therapeutic benefits of the Amazonian plant-based psychedelic "ayahuasca" for neuropsychiatric disorders such as depression and anxiety. However, there are certain challenges when incorporating botanical ayahuasca into biomedical research and clinical therapy environments. Formulations inspired by ayahuasca, which contain specific and standardized...