Changes in DNA Methylation Associated With Psychobehavioral Interventions: A Scoping Literature Review.
Biological Research for Nursing May 31, 2025 Karen L Saban, Linda Janusek, Paula de la Pena et al. 3 citations
DNA methylation, an epigenetic process that modifies gene expression and can alter physiological responses to psychological stress, is malleable and may be changed by psychobehavioral interventions such as mindfulness-based stress reduction, cognitive behavioral therapy, and yoga. This scoping review of 21 studies found that several reported differences in DNA methylation in response to such interventions across genes related to stress and inflammation, though many studies were inadequately powered. Studies varied widely in participant health status, intervention type and duration, biospecimens examined, and DNA analysis methods. Future research needs to address design limitations, evaluate biological importance, and link DNA methylation changes to physiological and psychological outcomes.