Ketamine in clinical practice: transitioning from anesthetic agent to psychiatric therapeutic.
CNS Spectrums June 30, 2025 Jose-Manuel Quintero, Rosa-Helena Bustos, Sharon Lechtig-Wassermann et al. 6 citations
Ketamine, originally synthesized in 1962, has gained increasing attention due to its rapid and sustained antidepressant effects in treatment-resistant depression (TRD). Unlike traditional antidepressants, ketamine acts on multiple neurotransmitter systems, including NMDA receptor antagonism and AMPA receptor potentiation, offering a novel mechanism for mood regulation. Beyond psychiatry,...
DOI: 10.1017/S1092852925100333 (opens in new tab)
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Ketamine
Anesthetic
Recreational drug
Antidepressant therapy
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