Microglial BDNF modulates arketamine's antidepressant-like effects through cortico-accumbal pathways.
Science Advances July 11, 2025 Lujuan He, Xuenan Wang, Shilin Luo et al. 8 citations
Arketamine, the (R)-enantiomer of (R,S)-ketamine, shows even greater rapid and sustained antidepressant-like effects in rodent models compared to esketamine, yet the underlying mechanisms remain unclear. In this study, we used the chronic social defeat stress (CSDS) model to investigate how arketamine exerts its antidepressant-like effects. We found that activating cAMP response element-binding...