LSD Restores Synaptic Plasticity in VTA of Morphine-Treated Mice and Disrupts Morphine-Conditioned Place Preference.
bioRxiv : the preprint server for biology June 15, 2025 Michael Von Gunten, Tenna Russell, Isaac Stirland et al. preprint
Psychedelics are emerging as a promising treatment option for a range of neuropsychiatric disorders, including substance use disorders. One potential mechanism underlying their therapeutic benefits may involve a reversal of maladaptive plasticity induced by drug exposure. Here, we identify physiological, behavioral, and epigenetic impacts of lysergic acid diethylamide (LSD) on morphine-treated...
DOI: 10.1101/2025.06.12.658958 (opens in new tab)
Full text (opens in new tab)
Psychedelic therapy
Addiction treatment
Opioid addiction