Generative modelling of the thalamo-cortical circuit mechanisms underlying the neurophysiological effects of ketamine
bioRxiv Preprint Server May 5, 2020 Alexander D Shaw, Suresh Muthukumaraswamy, Neeraj K. Saxena et al. 2 citations preprint
Cortical recordings of task-induced oscillations following subanaesthetic ketamine administration demonstrate alterations in amplitude, including increases at high-frequencies (gamma) and reductions at low frequencies (theta, alpha). To investigate the population-level interactions underlying these changes, we implemented a thalamo-cortical model (TCM) capable of recapitulating broadband...