Ketamine decreases HPA axis reactivity to a novel stressor in male but not female mice
bioRxiv Preprint Server June 29, 2021 Colin J. Johnston, Paul J. Fitzgerald, Jena S. Gewarges et al. 5 citations preprint
Ketamine is an antidepressant drug that interacts with the hypothalamic-pituitary-adrenal (HPA) axis, but whether this interaction is important for its behavioral effect is unknown. The goal of this experiment was to determine whether the behavioral response to ketamine depends on intact HPA axis function. Male and female C57BL/6J mice underwent chronic unpredictable stress prior to ketamine...