N1 cassette-lacking NMDA receptors mediate the antidepressant activity of ketamine
bioRxiv Preprint Server April 12, 2025 Alina T. He, Wenbo Zhang, Hongbin Li et al. preprint
Ketamine has emerged as a rapid-acting and robust antidepressant1,2. However, the mechanism of its antidepressant action remains enigmatic. The core issue that has yet to be resolved is whether NMDA receptors (NMDARs), which are subject to open channel blockade by ketamine3,4, mediate the antidepressant effect. NMDARs naturally undergo alternative splicing of the obligatory GluN1 subunit5,...