Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity
bioRxiv Preprint Server December 29, 2022 Marc Duque, Alex B. Chen, Eric Hsu et al. 1 citation preprint
Mood-altering compounds hold promise for the treatment of many psychiatric disorders, such as depression, but connecting their molecular, circuit, and behavioral effects has been challenging. Here we find that, analogous to effects in rodent learned helplessness models, ketamine pre-exposure persistently suppresses futility-induced passivity in larval zebrafish. While antidepressants are...