Ketamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in mice
bioRxiv Preprint Server January 22, 2020 Greer McKendrick, Hannah Garrett, Holly E. Jones et al. 1 citation preprint
Patients suffering from opioid use disorder often relapse during periods of abstinence, which is posited to be caused by negative affective states that drive motivated behaviors. Here, we explored whether conditioning mice with morphine in a CPP training paradigm evoked anxietylike behavior during morphine abstinence. To do this, mice were conditioned with morphine (10 mg/kg, i.p.) for five...