Interaction between perineuronal nets and ketamine in antidepressant action
bioRxiv Preprint Server May 30, 2021 Calvin K. Young, Kachina G. Kinley, Neil McNaughton preprint
Depression is highly prevalent, increases suicide risk, and is now the leading cause of disability worldwide. Our ability to treat depression is hampered by the lack of understanding of its biological underpinnings and of the mode of action of effective treatments. We hypothesised that the scaffolding proteins in the medial frontal cortex play a major role in effective antidepressant action. We...