Grace N Jang

Ketamine Produces a Long-Lasting Enhancement of CA1 Neuron Excitability

bioRxiv Preprint Server May 26, 2021 Grace N Jang, M Bruce MacIver 1 citation preprint

Background Ketamine is a clinical anaesthetic and a fast-acting, long-lasting antidepressant. Ketamine is known for its antagonistic actions on N-methyl-D-aspartate (NMDA) receptors, but mechanisms leading to antidepression are not clear. The present study examined synaptic, neuronal and circuit-level loci, the duration of ketamine’s actions, and the involvement of NMDA receptors in these actions.