Ketamine potentiates a central glutamatergic presynapse
bioRxiv Preprint Server December 17, 2023 Abdelmoneim Eshra, Noa Lipstein, Stefan Hallermann 1 citation preprint
Ketamine produces rapid and sustained antidepressant effects after brief exposure to a single dose. Counterintuitively, while ketamine acts primarily as a blocker of postsynaptic N-methyl-D-aspartate receptors (NMDARs), increased signalling at glutamatergic synapses has been reported. Due to technical limitations, however, it remains unclear whether ketamine directly increases presynaptic...