Nuria Mackes

Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission from Depression

medRxiv Preprint Server December 7, 2020 Vasileia Kotoula, Argyris Stringaris, Nuria Mackes et al. 9 citations preprint

Ketamine as an antidepressant improves anhedonia, a pernicious symptom of depression as early as 2h post-infusion. The effects of ketamine on anhedonia are thought to be exerted via actions on reward-related brain areas—yet, these actions remain largely unknown. This study examines ketamine’s effects during the anticipation and receipt of an expected reward, after the psychotomimetic effects of...