Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission from Depression
medRxiv Preprint Server December 7, 2020 Vasileia Kotoula, Argyris Stringaris, Nuria Mackes et al. 9 citations preprint
Ketamine as an antidepressant improves anhedonia, a pernicious symptom of depression as early as 2h post-infusion. The effects of ketamine on anhedonia are thought to be exerted via actions on reward-related brain areas—yet, these actions remain largely unknown. This study examines ketamine’s effects during the anticipation and receipt of an expected reward, after the psychotomimetic effects of...