Age affects temporal response, but not durability, to serial ketamine infusions for treatment refractory depression
medRxiv Preprint Server August 31, 2020 Steven Pennybaker, Brian J Roach, Susanna L Fryer et al. preprint
Background Ketamine is a rapid-acting treatment for patients with treatment refractory depression (TRD), however treatment responses are often transient and ketamine’s antidepressant action lacks robust clinical durability. Little is known about which patient characteristics are associated with faster or more durable ketamine responses. Ketamine’s antidepressant mechanism is proposed to involve...