Hans-Christian Stein

2 papers in the library · 3 citations · publishing 2022-2025

Papers

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A randomized, double-blind, placebo-controlled, Phase 1 study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of an immediate-release oral ketamine capsule in healthy volunteers.

Journal of Psychopharmacology June 20, 2025 Mutahira Qureshi, Daniel Silman, Romayne Gadelrab et al. 3 citations

Ketamine, a rapid-acting N-methyl-D-aspartate receptor antagonist used as a therapeutic for treatment-resistant depression (TRD), is usually administered intravenously or intranasally. This randomized, double-blind, placebo-controlled, Phase 1 study investigated safety and tolerability (primary endpoint), pharmacokinetics (PK) and pharmacodynamics (PD) of an immediate-release oral ketamine....

DOI: 10.1177/02698811251340925 Full text Ketamine Pharmacokinetics Pharmacodynamics Tolerability +2

Aggressiveness in the dreams of drug-naïve and clonazepam-treated patients with isolated REM sleep behavior disorder.

Sleep Medicine April 1, 2022 Simone Cavallotti, Hans-Christian Stein, Mariantonietta Savarese et al.

Although aggressive dream content is considered a distinctive feature of REM Sleep Behavior Disorder (RBD) and patients often report violent dreams during medical interviews, nonviolent behaviors (eating, drinking, urinating) and pleasant actions (e.g laughing, singing, dancing) or simply elemental, jerky limb movements are frequently observed during video-polysomnography. As a first-line...

DOI: 10.1016/j.sleep.2022.02.022 Full text Dream content Aggressiveness Clonazepam