The role of benzodiazepine receptors in the discriminative stimulus properties of delta-9-tetrahydrocannabinol.
Life Sciences April 28, 1986 D J Mokler, B D Nelson, L S Harris et al.
Twenty male Sprague-Dawley rats were trained to discriminate 3.0 mg/kg delta-9-tetrahydrocannabinol (THC) from its vehicle. Following acquisition of this discrimination animals were tested for generalization to 3.0 mg/kg diazepam. Thirteen animals showed a generalization from THC to diazepam, whereas the remaining seven animals did not. The generalization curve for diazepam was dose-dependent...