3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain.
European Journal of Pharmacology June 4, 1987 G A Ricaurte, K F Finnegan, D E Nichols et al.
The present study was carried out to asses possible toxic effects of 3,4-methylenedioxyethylamphetamine (MDE) on serotonergic, dopaminergic or noradrenergic neurons in the rat brain. It was found that MDE produced a long-lasting, dose-related depletion of serotonin (5HT). However, even at high dosage, MDE did not reduce the concentration of either dopamine (DA) or norepinephrine (NE) on a...