Effect of flunarizine and nimodipine on the decrease in tryptophan hydroxylase activity induced by methamphetamine and 3,4-methylenedioxymethamphetamine.
Journal of Pharmacology and Experimental Therapeutics May 1, 1992 M Johnson, K Mitros, D M Stone et al.
The effect of calcium channel blockers on the decrease in central tryptophan hydroxylase (TPH) activity and serotonin (5-HT) concentration induced by repeated large doses of methamphetamine (METH) or 3,4-methylenedioxymethamphetamine (MDMA) was evaluated. Rats received four or five injections of METH (10 or 15 mg/kg) or MDMA (10 mg/kg) at 6-h intervals, and were sacrificed 18 to 20 h or 1 week...
DOI: 10.1016/s0022-3565(25)11079-3 (opens in new tab)
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Serotonin
Brain
Animals
Rats, inbred strains
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