Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release.
Neuropsychopharmacology May 1, 1993 N L Rempel, C W Callaway, Mark A. Geyer
The locomotor hyperactivity induced by 3,4-methylene-dioxymethamphetamine (MDMA) and related drugs in rats appears to be due to the drug-induced release of presynaptic serotonin (5-HT). Thus, these drugs increase locomotor activity by acting as indirect 5-HT agonists. The subtype of 5-HT receptor upon which this released 5-HT acts postsynaptically to produce the activating effect of MDMA-like...
DOI: 10.1038/npp.1993.22 (opens in new tab)
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Synapses
Animals
Rats, sprague-dawley
Propranolol
+14