Low-dose ketamine modulates brain entropy in treatment-resistant depression: Results from two neuroimaging clinical trials.
Journal of Affective Disorders October 26, 2026 Ying-Jay Liou, Li-Kai Cheng, Wei-Chen Lin et al.
Several studies have reported entropy reductions in regions of the brain associated with affective-regulatory and reward- and motivation-related processes in patients with major depressive disorder. However, whether low-dose ketamine modulates this reduction remains unclear. We analyzed resting-state functional magnetic resonance imaging data from two single-infusion low-dose ketamine trials....
DOI: 10.1016/j.jad.2026.122673 (opens in new tab)
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Treatment-resistant depression
Amygdala
Brain entropy
Clinical trial
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