Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity.
Bioorganic & Medicinal Chemistry July 1, 2014 Mark A Tepper, Robert B Zurier, Sumner H Burstein
Ajulemic acid, a side-chain analog of Δ(8)-THC-11-oic acid, was designed as a potent therapeutic agent free of the psychotropic adverse effects typical of most cannabinoids. Subsequent studies of ajulemic acid have yielded widely divergent findings on the occurrence of these adverse effects. To help resolve these discrepancies, we have prepared highly purified ajulemic acid using a different...
DOI: 10.1016/j.bmc.2014.04.062 (opens in new tab)
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Ajulemic acid
Cannabinoid receptors
Synthesis