Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro.
European Neuropsychopharmacology September 2013 Ran Barzilay, Javier Ganz, Ofer Sadan et al.
Mesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine strategies in brain diseases. Experimental studies have shown that repeated administration of phencyclidine (PCP) leads to schizophrenia-like behavioral changes in mice. The aim of the present study was to explore the effectiveness of MSC transplantation into the hippocampus in attenuating PCP-induced social...
DOI: 10.1016/j.euroneuro.2012.10.002 (opens in new tab)
Full text (opens in new tab)
Animal model
Phencyclidine
Regenerative medicine
Schizophrenia
+2