Acute administration of Δ⁹ tetrahydrocannabinol does not prevent enhancement of sensory gating by clozapine in DBA/2 mice.
Pharmacology, Biochemistry, and Behavior March 2014 Jason Smucny, Karen E Stevens, Jason R Tregellas
Despite high rates of marijuana abuse in schizophrenia, the physiological interactions between tetrahydrocannabinol (THC) and antipsychotic medications are poorly understood. A well-characterized feature of schizophrenia is poor gating of the P50 auditory-evoked potential. This feature has been translationally modeled by the DBA/2 mouse, which exhibits poor suppression of the P20-N40 AEP, the...
DOI: 10.1016/j.pbb.2014.01.001 (opens in new tab)
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Cannabinoid
Clozapine
Dba/2
Gating
+2