D A Lanshakov

Subanesthetic ketamine modulates region-specific neural and endocrine responses to acute stress in rats.

Neuropharmacology October 19, 2026 U S Drozd, V V Bulygina, G T Shishkina et al.

Exposure to acute, inescapable stress triggers a coordinated neural and endocrine response across corticolimbic and brainstem circuits. Although subanesthetic ketamine has rapid antidepressant effects, it is unclear whether its modulation of the stress-response network depends on the presence of an acute stressor. In this study, naïve rats received subanesthetic ketamine (15 mg/kg) or a...